© 2020 by Phenocell SAS - Photo credit : K. Garell, F. Simonnet, A. Peschanski and the Phenocell Team

 

Dermo-cosmetique

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standard phenotypic assays with 

Caucasian, African or Asian PCi cells

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Cell stress Facts

  • Human cells respond to adverse environmental conditions by adaptive mechanisms that include a variety of signaling pathways and, ultimately, by self-destruction.   

  • Adaptation allows cell survival if the stress is not too intense or prolonged.

  •   Mitochondria plays an instrumental role in cell survival against oxidative damage.

Cellular stress-related assays

Cell proliferation/Survival (sebocytes)

Ref. SEB-LCC

Endpoint: Nb live/dead cells

Method: Calcin AM - Annexin V*

Biological question: Cell proliferation - Survival

Cellular oxidative stress (melanocytes)

Ref. MEL-CRX

Endpoint: Cell ratio intensity of staining.

Method: Fluorescent marker

Biological question:  Oxidative stress response at cell level

Cell proliferation/Survival (melanocytes)

Ref. MEL-LCC

Endpoint: Nb live/dead cells

Method: Calcin AM - Annexin V*

Biological question: Cell proliferation - Survival

Cellular oxidative stress (sebocytes)

Ref. SEB-CRX

Endpoint: Cell ratio intensity of staining.

Method: Fluorescent marker

Biological question:  Oxidative stress response at cell level