Acne & hyperseborrhea research & testing platform 

1.png

R&D solutions for acne & hyperseborrhea

In order to open new horizons for scientific research in the field of acne and hyperseborrhea, and more specifically for the testing and screening of active pharmaceutical ingredients, Phenocell offers a new & exclusive human sebocyte model derived from induced pluripotent stem cells (iPSC). 

iPSC-derived sebocytes display all the key functional characteristics of normal human sebocytes, including sebum synthesis, while - unlike cell lines - retaining a normal karyotype. Due to their high genomic stability, their availability in almost unlimited quantities and their high level of inter-batch reproducibility, iPSC-derived cells are the most robust and relevant tool for the execution of your screening campaigns and R&D projects

AdobeStock_251064517 GRATUIT.jpg

Identify new pharmaceutical active ingredients with our selection of innovative high-throughput tests on iPSC-derived sebocytes!  

Robot pipettage_edited.jpg

Take advantage of the characteristics of a primoculture with the benefits of a cell line using iPSC-derived cells: 

  • high genomic stability

  • available in almost unlimited quantities 

  • high batch-to-batch reproducibility

iPSC-derived cells are the most relevant model for HTS studies on human cells!

Your iPSC-derived sebocyte screening campaign 

Starting from 4500€/96wp

High-throughput screening services for
acne & hyperseborrhea research & testing

A unique in vitro sebocyte model developed into 3 ethnicity-specific skin models

1.png
flèche scroling.png
flèche scroling.png

Biodiversity

Phenocell's acne & oily skin models are based on the use of iPSC-derived sebocytes from multiple donors:

  • Human iPSC-sebocytes differentiated from asian donors

  • Human iPSC-sebocytes differentiated from african donors
  • Human iPSC-sebocytes differentiated from caucasian donors

Cell culture format

Useful for ethnicity specific claim validation

Phenocell's iPCS-derived sebocytes model is available:

  • in monolayers (from 6 wp down to 96 wp)

  • in 3D culture (reconstructed human sebaceous gland model) 

iPSC-derived sebocytes.jpg
reconstructed sebaceous gland phenocell.jpg

Cell characterization

Phenocell's iPCS-derived sebocytes model is fully characterized:

  • Normal karyotype

  • High level of purity

  • Expression of key sebocyte markers
    (e.g. MUC1, KRT7, PPARg, FADS2, AR, MC5R)

  • Lipid synthesis

iPSC-derived sebocyte model - phenocell.jpg

Cell functionality

Phenocell's iPSC-derived sebocyte model is fully validated for testing:

  • Cell toxicity & cell survival

  • PPARs activation

  • Androgen receptor activation

  • Inflammation response  to LPS, Arachidonic acid, C. acnes

  • Sebogenesis and lipid synthesis (e.g. squalene, wax ester)

  • Response to cannabinoids

Sebocyte related assays fusion.webp
skin ehnic color 600PX PNG.png
logo download PDF 150px.png

Get a sample report on
iPSC-derived sebocyte model

fly butterfly.png

Thanks! Check your mailbox

sample report SEB phenocell.webp

Find bellow examples of acne & hyper/hyposeborrhea bioassays :

Seborrhea-related bioassays

If you do not find your favorite bioassays, do not worry,

Custom biological tests are available.

Contact us for more information.

Management of your R&D project

1

PICTO study work flow phenocell 1.png

2

PICTO study work flow phenocell 2.png

3

PICTO study work flow phenocell 3.png

4

PICTO study work flow phenocell 4.png

Preliminary study
NDA
Project framework
Feasibility study
Quotation
Service agreement, order

Experiment
Compound receipt
iPSC culture
Testing & Bioassays

Data management
Quality control
Data analysis
Data minding

Report

Report writing
Report meeting

 

flèche scroling.png

A project? A request?
We are here to support your R&D
Contact us to set up a visio call

fly butterfly.png
4.png

Thanks for your message, we will contact you soon.

Vidéoconférence
 
3.png

Some related products
if you choose to perform the assays in house