Acne & hyperseborrhea research & testing plateform 

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In order to open new horizons for scientific research in the field of acne and hyperseborrhea, and more specifically for the testing and screening of active pharmaceutical ingredients, Phenocell offers a new & exclusive human sebocyte model derived from induced pluripotent stem cells (iPSC). 

Screening solutions for acne & hyperseborrhea

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iPSC-derived sebocytes display all the key functional characteristics of normal human sebocytes, including sebum synthesis, while having, unlike cell lines, a normal karyotype. Due to their high genomic stability, their availability in almost unlimited quantities and their high level of inter-batch reproducibility, iPSC-derived cells are therefore the most robust and relevant tool for the execution of your screening campaigns

Identify new pharmaceutical active ingredients with our selection of innovative high-throughput tests on iPSC-derived sebocytes!  

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Take advantage of the characteristics of a primoculture with the benefits of a cell line using iPSC-derived cells: 

  • high genomic stability

  • available in almost unlimited quantities 

  • high batch-to-batch reproducibility

iPSC-derived cells are the most relevant model for HTS studies on human cells!

Your iPSC-derived sebocyte screening campaign 

Starting from 4500€/96wp

High-throughput screening services for
acne & hyperseborrhea research & testing

An in vitro sebocyte model
with the characteristics of primoculture
and the advantages of cell line

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Biodiversity

Phenocell's acne & oily skin model is based on the use of iPCS-derived sebocytes from multiple donors:

  • Human iPSC-sebocytes differentiated from asian donors

  • Human iPSC-sebocytes differentiated from african donors
  • Human iPSC-sebocytes differentiated from caucasian donors

Cell culture format

Useful for ethnic specific claim validation

Phenocell's iPCS-derived sebocytes model is available:

  • in monolayers (from 6 wp down to 96 wp)

  • in 3D culture (reconstructed human sebaceous-like gland model) 

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Cell characterization

Phenocell's iPCS-derived sebocytes model is fully characterized:

  • Normal kariotype

  • High level of purity

  • Expression of key sebocyte markers
    (e.g. MUC1, KRT7, PPARg, FADS2, AR, MC5R)

  • Lipid synthesis

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Cell functionality

Phenocell's iPSC-derived sebocytes model is useful and validate for testing:

  • Cell toxicity & cell survival

  • PPARs activation

  • Androgen receptor activation

  • Inflammation response  to LPS, Arachidonic acid, C. acnes

  • Sebogenesis and lipid synthesis (e.g. squalene, wax ester)

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Get a sample report on
iPSC-derived sebocyte model

Thanks! Check your box mails.

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Sebocyte related bioassays by phenocell

Find bellow some example of acne & hyperseborrhea related bioassays that Phenocell offer as service :

If you do not find your favorite bioassays, do not worry,

Custom biological tests are available.

Contact us for more information.

Management of your R&d project

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Preliminary study
NDA
Project framework
Feasibility study
Quotation
Service agreement, order

Experiment
Compound receipt
iPSC culture
Testing & Bioassays

Data management
Quality control
Data analysis
Data minding

Report

Report writing
Report meeting

 

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A project? A request?
We are here to support your R&D.
Contact us to discuss.

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Thanks for your message, we will contact you soon.

Vidéoconférence
 

Some related products
if you prefer to perform the assays in your lab!