Acne & hyperseborrhea research & testing platform
R&D solutions for acne & hyperseborrhea
In order to open new horizons for scientific research in the field of acne and hyperseborrhea, and more specifically for the testing and screening of active pharmaceutical ingredients, Phenocell offers a new & exclusive human sebocyte model derived from induced pluripotent stem cells (iPSC).
iPSC-derived sebocytes display all the key functional characteristics of normal human sebocytes, including sebum synthesis, while - unlike cell lines - retaining a normal karyotype. Due to their high genomic stability, their availability in almost unlimited quantities and their high level of inter-batch reproducibility, iPSC-derived cells are the most robust and relevant tool for the execution of your screening campaigns and R&D projects.
Identify new pharmaceutical active ingredients with our selection of innovative high-throughput tests on iPSC-derived sebocytes!
Take advantage of the characteristics of a primoculture with the benefits of a cell line using iPSC-derived cells:
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high genomic stability
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available in almost unlimited quantities
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high batch-to-batch reproducibility
iPSC-derived cells are the most relevant model for HTS studies on human cells!
Your iPSC-derived sebocyte screening campaign
Starting from 4500€/96wp
High-throughput screening services for
acne & hyperseborrhea research & testing
A unique in vitro sebocyte model developed into 3 ethnicity-specific skin models
Biodiversity
Phenocell's acne & oily skin models are based on the use of iPSC-derived sebocytes from multiple donors:
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Human iPSC-sebocytes differentiated from asian donors
- Human iPSC-sebocytes differentiated from african donors
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Human iPSC-sebocytes differentiated from caucasian donors
Cell culture format
Useful for ethnicity specific claim validation
Phenocell's iPCS-derived sebocytes model is available:
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in monolayers (from 6 wp down to 96 wp)
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in 3D culture (reconstructed human sebaceous gland model)
Cell characterization
Phenocell's iPCS-derived sebocytes model is fully characterized:
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Normal karyotype
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High level of purity
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Expression of key sebocyte markers
(e.g. MUC1, KRT7, PPARg, FADS2, AR, MC5R) -
Lipid synthesis
Cell functionality
Phenocell's iPSC-derived sebocyte model is fully validated for testing:
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Cell toxicity & cell survival
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PPARs activation
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Androgen receptor activation
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Inflammation response to LPS, Arachidonic acid, C. acnes
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Sebogenesis and lipid synthesis (e.g. squalene, wax ester)
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Response to cannabinoids
Get a sample report on
iPSC-derived sebocyte model
Seborrhea-related bioassays
Find bellow examples of acne & hyper/hyposeborrhea bioassays :
If you do not find your favorite bioassays, do not worry,
Custom biological tests are available.
Management of your R&D project
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Preliminary study
NDA
Project framework
Feasibility study
Quotation
Service agreement, order
Experiment
Compound receipt
iPSC culture
Testing & Bioassays
Data management
Quality control
Data analysis
Data minding
Report
Report writing
Report meeting
