Skin pigmentation
research & testing plateform 

Screening solutions for pigmentation research

iPSC-derived melanocytes display all the key functional characteristics of normal human melanocytes, including melanin synthesis, while having, unlike the cell line, a normal karyotype. Due to their high genomic stability, their availability in unlimited quantities and their high level of inter-batch reproducibility, iPSC-derived cells are therefore the most robust and relevant tool for the execution of your screening campaigns. 

Identify new pharmaceutical active ingredients with our selection of innovative high-throughput tests on iPSC-derived melanocytes!  

Take advantage of the characteristics of a primoculture with the benefits of a cell line using iPSC-derived cells: 

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• high genomic stability

• available in unlimited quantities 

• high batch-to-batch reproducibility

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iPSC-derived cells are the most relevant model for HTS studies on human cells!

An in vitro melanocyte model
with the characteristics of primoculture
and the advantages of cell line

Biodiversity

Phenocell's pigmentation model is based on the use of iPCS-derived melanocytes from multiple donors:

• Human iPSC-melanocytes differentiated from asian donors

• Human iPSC- differentiated from african donors

• Human iPSC-melanocytes differentiated from caucasian donors

• Human iPSC-melanocytes differentiated from albino donors

Useful for ethnic specific claim validation

Cell culture format

Phenocell's iPCS-derived melanocytes model is available:

• in monolayers (from 6 wp down to 96 wp)

Cell characterization

Phenocell's iPCS-derived melanocyte model is fully characterized:

• Normal kariotype

• High level of purity

• Expression of key melanocyte markers
  (e.g. PAX3, MITF, PMEL17, TRYP1)

• Melanin synthesis

Cell functionality

Phenocell's iPSC-derived melanocyte  model is useful and validate for testing:

• Cell toxicity & cell survival

• Oxydative stress

• Melanongenesis related markers (e.g. Pmel17, TYR, TRYP1, MITF)

• Melanin synthesis (pro and anti-pigmentating effect) 

Get a sample report on
iPSC-derived melanocyte model