Skin pigmentation
research & testing platform 

R&D solutions for pigmentation research

In order to open new horizons for scientific research in the field of pigmentation and more specifically for the testing and screening of active dermo-cosmetic ingredients, Phenocell has developed a new & exclusive human melanocyte model based on induced pluripotent stem cells (iPSC). 

iPSC-derived melanocytes display all the key functional characteristics of normal human melanocytes, including melanin synthesis, while having - unlike immortalized melanocytes - a normal karyotype. Due to their high genomic stability, their availability in unlimited quantities and their high level of inter-batch reproducibility, iPSC-derived cells are the most robust and relevant tool for the execution of your screening campaigns and R&D projects. 

Identify and characterize new pharmaceutical active ingredients with our selection of innovative high-throughput tests on iPSC-derived melanocytes!  

Take advantage of the characteristics of a primoculture with the benefits of a cell line using iPSC-derived cells: 

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• high genomic stability

• available in unlimited quantities 

• high batch-to-batch reproducibility

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iPSC-derived cells are the most relevant model for HTS studies on human cells!

An in vitro melanocyte model
close to reality

Biodiversity

Phenocell's pigmentation model is based on the use of iPCS-derived melanocytes from multiple donors:

• Human iPSC-melanocytes from asian donors

• Human iPSC-melanocytes from african donors

• Human iPSC-melanocytes from caucasian donors

• Human iPSC-melanocytes from albino donors

Useful for ethnicity-specific claim validation

Cell culture format

Phenocell's iPCS-derived melanocytes model is available:

• in monolayers (from 6 wp down to 96 wp)

Cell characterization

Phenocell's iPCS-derived melanocyte are fully characterized:

• Normal karyotype

• High level of purity (>90%)

• Expression of key melanocyte markers
  (e.g. PAX3, MITF, PMEL17, TRYP1)

• Melanin synthesis

• Melanosome transfer to keratinocytes

Cell functionality

Phenocell's iPSC-derived melanocyte  are useful and validated for testing:

• Cell toxicity & cell survival

• Oxydative stress

• Melanongenesis related markers (e.g. Pmel17, TYR, TRYP1, MITF)

• Melanin synthesis (pro and anti-pigmentating effect) 

Get a sample report on
iPSC-derived melanocyte model

Management of your R&D project