Skin pigmentation
research & testing platform 

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R&D solutions for pigmentation research

In order to open new horizons for scientific research in the field of pigmentation and more specifically for the testing and screening of active dermo-cosmetic ingredients, Phenocell has developed a new & exclusive human melanocyte model based on induced pluripotent stem cells (iPSC). 

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iPSC-derived melanocytes display all the key functional characteristics of normal human melanocytes, including melanin synthesis, while having - unlike immortalized melanocytes - a normal karyotype. Due to their high genomic stability, their availability in unlimited quantities and their high level of inter-batch reproducibility, iPSC-derived cells are the most robust and relevant tool for the execution of your screening campaigns and R&D projects

Identify and characterize new pharmaceutical active ingredients with our selection of innovative high-throughput tests on iPSC-derived melanocytes!  

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Take advantage of the characteristics of a primoculture with the benefits of a cell line using iPSC-derived cells: 

  • high genomic stability

  • available in unlimited quantities 

  • high batch-to-batch reproducibility

iPSC-derived cells are the most relevant model for HTS studies on human cells!

Your iPSC-derived melanocyte screening campaign 

Starting from
4500€/96wp

High-throughput screening services for
pigmentation research & testing

An in vitro melanocyte model
close to reality

Biodiversity

Phenocell's pigmentation model is based on the use of iPCS-derived melanocytes from multiple donors:

  • Human iPSC-melanocytes from asian donors

  • Human iPSC-melanocytes from african donors
  • Human iPSC-melanocytes from caucasian donors

  • Human iPSC-melanocytes from albino donors

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Useful for ethnicity-specific claim validation

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Cell culture format

Phenocell's iPCS-derived melanocytes model is available:

  • in monolayers (from 6 wp down to 96 wp)

Cell characterization

Phenocell's iPCS-derived melanocyte are fully characterized:

  • Normal karyotype

  • High level of purity (>90%)

  • Expression of key melanocyte markers
    (e.g. PAX3, MITF, PMEL17, TRYP1)

  • Melanin synthesis

  • Melanosome transfer to keratinocytes

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Cell functionality

Phenocell's iPSC-derived melanocyte  are useful and validated for testing:

  • Cell toxicity & cell survival

  • Oxydative stress

  • Melanongenesis related markers (e.g. Pmel17, TYR, TRYP1, MITF)

  • Melanin synthesis (pro and anti-pigmentating effect) 

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Get a sample report on
iPSC-derived melanocyte model

Thanks! Check your mailbox

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Melanogenesis-related bioassays 

Bellow are examples of pigmentation-related bioassays that Phenocell offers as service :

If you do not find your favorite bioassays, do not worry,

Custom biological tests are available.

Contact us for more information.

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Management of your R&D project

Preliminary study
NDA
Project framework
Feasibility study
Quotation
Service agreement, order

Experiment
Compound receipt
iPSC culture
Testing & Bioassays

Data management
Quality control
Data analysis
Data minding

Report

Report writing
Report meeting

 

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A project? A request?
We are here to help your R&D
Contact us !

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Vidéoconférence
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Some related products
if you choose to perform the assays in house