© 2019 by Phenocell SAS - Photo credit : Kim Garell, F. Simonnet and the Phenocell Team

Pharmacology

Phenotypic assays with iPSC-derived cells help deciphering the full range of molecular mechanisms affected by the pathology. Efficacy and toxicity assays become relevant.

Straightforward answers with

iPSC and phenotypic assays

250 lead compounds screened from a million compounds enter pre-clinical testing

10 of them will proceed to clinical trial

1 will be approved by regulatory authorities

For one-third, pre-clinical investigations of the drug development process are performed using cellular tools.

Increasing the relevance of those tools to the pathophysiological situation greatly improves drug screening efficacy and limits the occurrence of false-positive molecules

 

Our assays are designed to monitor crucial physiological functions, including:

cell death

cell proliferation

DNA repair

axonal elongation and branching (Neural stem cells)

Shift from target-based to phenotypic assays with PhenoTests

Why iPSC ?

Induced pluripotent stem cells (iPSC) are cells with the characteristics of embryonic stem cells, generated from an adult cell.

iPSC possess the ability to self-renew, or multiply identically in vitro. They also retain the ability to form any type of cell of the Human body, a property called pluripotency.

Self-renewal, or unlimited expansion, allows generating billions of cells nearly identical to perform long-term studies. Pluripotency affords the possibility to obtain all cellular models needed to study a single pathophysiological situation.

IPSC are unique tools for pathophysiological modeling and compound assessment. They are used worldwide by more than 2000 research teams, in academia and the pharmaceutical and cosmetic industry.

Why Phenocell

Phenocell has acquired a premium expertise in human iPSC production (more than 180 iPSC lines since inception) and had developed robust processes to differentiate iPSC into skin cells.

 

Our offer of skin cells (sebocytes, melanocytes and keratinocytes) from a variety of ethnic backgrounds is unique worldwide.

Each cell type comes with a panel of bioassays to target the main functions and dysfunction of the human skin.