Dermo-cosmetics

Pigmentation

Hyperpigmentation is a skin condition that occur in people usually due to an unhealthy or higher production of a pigment called melanin, produced by melanocytes.
Hypopigmentation refers to a loss of melanin production related to genetic condition (albinism, vitiligo, atopic dermatitis, ...) or injury (burns).
Voluntary modification of skin pigmentation can be cultural.

Melanin determination

Ref. MEL-MLN

Endpoint: Concentration in melanin

Method: OD475 reading - photometry

Biological question: Pigmentation

mRNA expression

Ref. MEL-RNA

Endpoint: Relative expression level. All genes

Method: RT-qPCR

Biological question: Pigmentation disorder, melanogenesis pathway

Tyrosinase expression

Ref. MEL-TYR

Endpoint: Cell ratio intensity of staining

Method: Fluorescence imaging

Biological question: Pigmentation

MITF expression

Ref. MEL-MITF

Endpoint: MITF immunolabeling

Method: Immuno-fluorescence

Biological question: Key transcription factor, melanogenesis

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